The Social Influence Enhanced by the Mass Media Broadcasting in Innovation Diffusion

Based on the Bass model and the micro-model of mass media network, we propose an agent-based threshold approach including the mutual interaction between social relationship network and mass media network. Taking the heterogeneity of individuals into account, it is found that the direct advertisement from mass media broadcasting will attract the potential adopters greatly at the beginning of innovation diffusion. In the middle of diffusion process, the previous adopters formalize a positive feedback to the potential adopters via mass media broadcasting. The social collective effect can be strongly enhanced if the potential adopter prefer to mass media broadcasting. Furthermore, it is found that the complexity of the social relationship network may postpone the social collective effect

Kooperativna evolucija za kvalitetno pružanje usluga u paradigmi Interneta stvari

To facilitate the automation process in the Internet of Things, the research issue of distinguishing prospective services out of many “similar” services, and identifying needed services w.r.t the criteria of Quality of Service (QoS), becomes very important. To address this aim, we propose heuristic optimization, as a robust and efficient approach for solving complex real world problems. Accordingly, this paper devises a cooperative evolution approach for service composition under the restrictions of QoS. A series of effective strategies are presented for this problem, which include an enhanced local best first strategy and a global best strategy that introduces perturbations. Simulation traces collected from real measurements are used for evaluating the proposed algorithms under different service composition scales that indicate that the proposed cooperative evolution approach conducts highly efficient search with stability and rapid convergence. The proposed algorithm also makes a well-designed trade-off between the population diversity and the selection pressure when the service compositions occur on a large scale.Kako bi se automatizirali procesi u internetu stvati, nužno je rezlikovati bitne usluge u moru sličnih kao i identificirati potrebne usluge u pogledu kvalitete usluge (QoS). Kako bi doskočili ovome problemu prdlaže se heuristička optimizacija kao robustan i efikasan način rješavajne kompleksnih problema. Nadalje, u članku je predložen postupak kooperativne evolucije za slaganje usluga uz ograničenja u pogledu kvalutete usluge. Predstavljen je niz efektivnih strategija za spomenuti problem uključujući strategije najboljeg prvog i najboljeg globalnog koje unose perturbacije u polazni problem. Simulacijski rezultati kao i stvarni podatci su korišteni u svrhu evaluacije prodloženog algoritma kako bi se osigurala efikasna pretraga uz stabilnost i brzu konvergenciju. Predloženi algoritam tako.er vodi računa o odnosu izme.u različitosti populacije i selekcijskog pritiska kada je potrebno osigurati slaganje usluga na velikoj skali

THE ASSOCIATION OF ADULT MALE AND FEMALE INFERTILITY WITH CELIAC DISEASE PATIENTS IN YEMEN

Objectives: Celiac disease’s potentially destructive effect on reproductive health is among the most vital matters associated with progress awareness. Men and women with unexplained infertility, women with recurrent abortions, intrauterine growth retardation, low birth weight babies and menstrual disorders are not often screened for celiac disease (CD) despite scientific studies that point to a correlation. The aims of the present study were to examine the evidence of the correlation between CD and infertility by measuring sex hormones in CD comparing healthy controls (HC). Methods: The study was carried out in Autoimmune Unit, AL-Thowra Hospital Sana’a city, Yemen. The study included 32 CD patients, and 32 HC. Blood samples were collected then examined for sex hormones in both. Results:  There was highly significant low down level of the mean±SD of sex hormones among male and female CD than HC: for male CD FSH=1.96±1.4 IU/ml vs 3.3±1.27 IU/ml of HC, LH=3.9±3.3 IU/ml vs 6.5±2.03 IU/ml of HC; and the testosterone=1.03±0.76 IU/ml, vs 3.8±1.4 IU/ml of HC. For CD females the mean ± SD of FSH, for CD females was 4.37±2.46 IU/ml vs 4.92±2.35 IU/ml of HC, Estradiol (40.7±30.8 IU/ml vs 7.1±76.66 IU/ml of HC), and Progestrone (1.2±1.15 IU/ml, vs 6.4±4.38 IU/ml of HC). Conclusion:  In conclusion, there was significant association between CD and infertility among Yemeni CD patients in which it indicated by low sex hormones in CD patients. Peer Review History: Received 6 December 2017;   Revised 3 January; Accepted 8 January, Available online 15 January 2018 Academic Editor: Dr. Emmanuel O. Olorunsola, Department of Pharmaceutics & Pharmaceutical Technology, University of Uyo, Nigeria, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file:        Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Dr. Sameh Abdelmoneem Mohammed Ali, Faculty of Pharmacy, Beni-Suef University, Egypt, [email protected] Dr. Sunita Singh, Baylor College of Medicine, Houston, Texas, USA, [email protected] Similar Articles: PREVALENCE OF CYTOMEGALOVIRUS IGG ANTIBODIES, POTENTIAL RISK FACTORS AND AWARENESS OF CONGENITAL CYTOMEGALOVIRUS AMONG FEMALE DOCTOR

Human ring chromosome registry for cases in the Chinese population: re-emphasizing Cytogenomic and clinical heterogeneity and reviewing diagnostic and treatment strategies

Abstract Background Constitutional ring chromosomes are rare orphan chromosomal disorders. Ring chromosome syndrome featuring growth retardation and mild to intermediate intellectual disability is likely caused by the dynamic behavior of ring chromosome through cell cycles. Chromosomal and regional specific phenotypes likely result from segmental losses and gains during the ring formation. Although recent applications of genomic copy number and sequencing analyses revealed various ring chromosome structures from an increasing number of case studies, there was no organized effort for compilating and curating cytogenomic and clinical finding for ring chromosomes. Methods A web-based interactive ‘Human Ring Chromosome Registry’ using Microsoft Access based relational database was developed to present genetic and phenotypic findings of ring chromosome cases. Chinese ring chromosome cases reported in the literature was reviewed and compiled as a testing data set to validate this registry. Results A total of 113 cases of ring chromosomes were retrieved in all chromosomes except for chromosomes 16, 17 and 19. The most frequently seen ring chromosomes by a decreasing order of relative frequencies were ring 13 (14%), X (12%), 22 (10%), 15 (9%), 14 (7%), and 18 (7%). Genomic imbalances were detected in 18 out of 19 cases analyzed by microarray or sequencing. Variable clinical manifestations of developmental delay, dysmorphic facial features, intellectual disability, microcephaly, and hypotonia were noted in most autosomal rings. Chromosomal specific syndromic phenotypes included Wolf-Hirschhorn syndrome in a ring chromosome 4, cri-du-chat syndrome in a ring chromosome 5, epilepsy in ring chromosomes 14 and 20, Turner syndrome in ring chromosome X, and infertility in ring chromosomes 13, 21, 22 and Y. Effective growth hormone supplemental treatment for growth retardation in a ring chromosome 18 was noted. Conclusions Based on findings from these Chinese ring chromosome cases, guidelines for cytogenomic diagnosis and criteria for case registration were proposed. Further research to define underlying mechanisms of ring chromosome formation and dynamic mosaicism, to delineate the genotype-phenotype correlations, and to develop chromosome therapy for ring chromosomes were discussed

a novel bayesian network structure learning algorithm based on maximal information coefficient

Greedy Equivalent Search (GES) is an effective algorithm for Bayesian network problem, which searches in the space of graph equivalence classes. However, original GES may easily fall into local optimization trap because of empty initial structure. In this paper, An improved GES method is prosposed. It firstly makes a draft of the real network, based on Maximum Information Coefficient (MIC) and conditional independence tests. After this step, many independent relations can be found. To ensure correctness, then this draft is used to be a seed structure of original GES algorithm. Numerical experiment on four standard networks shows that NEtoGS (the number of graph structure, which is equivalent to the God Standard network) has big improvement. Also, the total of learning time are greatly reduced. Therefore, our improved method can relatively quickly determine the structure graph with highest degree of data matching. © 2012 IEEE.IEEE Nanjing SectionGreedy Equivalent Search (GES) is an effective algorithm for Bayesian network problem, which searches in the space of graph equivalence classes. However, original GES may easily fall into local optimization trap because of empty initial structure. In this paper, An improved GES method is prosposed. It firstly makes a draft of the real network, based on Maximum Information Coefficient (MIC) and conditional independence tests. After this step, many independent relations can be found. To ensure correctness, then this draft is used to be a seed structure of original GES algorithm. Numerical experiment on four standard networks shows that NEtoGS (the number of graph structure, which is equivalent to the God Standard network) has big improvement. Also, the total of learning time are greatly reduced. Therefore, our improved method can relatively quickly determine the structure graph with highest degree of data matching. © 2012 IEEE

a nosql based cached storage solution of gis web service

One of challenges in GIS Web service is mass GIS data storage and processing. There are at least three obstacles that oppose dealing with this challenge: the mismatch between the frequent requirement of concurrent tasks for accessing data in GIS Web service and the poor performance of conventional storage mechanism such as relational databases; the insufficiency of relational databases to manage complex data types in GIS Web service; the horizontal scalability of storage for non-stop GIS Web service evolution. This paper proposes a distributed cached storage solution, as the mixture of MongoDB storage and Memcached cache, for GIS Web service. Both techniques are closely related to NoSQL that is a class of database management system identified by its non-adherence to the widely used relational database management system (RDBMS) model. A concise case that facilitates a better understanding of this work indicates its feasibility.One of challenges in GIS Web service is mass GIS data storage and processing. There are at least three obstacles that oppose dealing with this challenge: the mismatch between the frequent requirement of concurrent tasks for accessing data in GIS Web service and the poor performance of conventional storage mechanism such as relational databases; the insufficiency of relational databases to manage complex data types in GIS Web service; the horizontal scalability of storage for non-stop GIS Web service evolution. This paper proposes a distributed cached storage solution, as the mixture of MongoDB storage and Memcached cache, for GIS Web service. Both techniques are closely related to NoSQL that is a class of database management system identified by its non-adherence to the widely used relational database management system (RDBMS) model. A concise case that facilitates a better understanding of this work indicates its feasibility

Additional file 1: of Human ring chromosome registry for cases in the Chinese population: re-emphasizing Cytogenomic and clinical heterogeneity and reviewing diagnostic and treatment strategies

Table S1. Chinese ring chromosome cases reported in the literature (XLSX 69 kb

Correlating genomic copy number alterations with clinicopathologic findings in 75 cases of hepatocellular carcinoma

Abstract Background Oligonucleotide array comparative genomic hybridization (aCGH) analysis has been used for detecting somatic copy number alterations (CNAs) in various types of tumors. This study aimed to assess the clinical utility of aCGH for cases of hepatocellular carcinoma (HCC) and to evaluate the correlation between CNAs and clinicopathologic findings. Methods aCGH was performed on 75 HCC cases with paired DNA samples from tumor and adjacent nontumor tissues. Survival outcomes from these cases were analyzed based on Barcelona-Clinic Liver Cancer Stage (BCLC), Edmondson-Steiner grade (E-S), and recurrence status. Correlation of CNAs with clinicopathologic findings was analyzed by Wilcoxon rank test and clustering vs. K means. Results The survival outcomes indicated that BCLC stages and recurrence status could be predictors and E-S grades could be a modifier for HCC. The most common CNAs involved gains of 1q and 8q and a loss of 16q (50%), losses of 4q and 17p and a gain of 5p (40%), and losses of 8p and 13q (30%). Analyses of genomic profiles and clusters identified that losses of 4q13.2q35.2 and 10q22.3q26.13 seen in cases of stage A, grade III and nonrecurrence were likely correlated with good survival, while loss of 1p36.31p22.1 and gains of 2q11.2q21.2 and 20p13p11.1 seen in cases of stage C, grade III and recurrence were possibly correlated with worst prognosis. Conclusions These results indicated that aCGH analysis could be used to detect recurrent CNAs and involved key genes and pathways in patients with HCC. Further analysis on a large case series to validate the correlation of CNAs with clinicopathologic findings of HCC could provide information to interpret CNAs and predict prognosis